Completed projects

Many European projects in which Watchfrog has participated have already been completed.

Here is a list of the projects we have worked on.

PACQUE

The PACQUE project aimed to develop a method for identifying the substances that have the greatest impact on the physiology of aquatic organisms among the thousands of substances present in surface water.
The product marketed following the project combines an optimized sampling strategy with the joint performance of bioassays and chemical fingerprints.

Partners:

Laboratoire Watchfrog

Financing:

ADEME/PIA

NANOCO

The impact on endocrine functions of metallic NANOparticles alone and in mixture with endocrine disrupting organic compounds for the analysis of the cocktail effect.

Partners:

Laboratoire Watchfrog, CEA – Grenoble

Financing:

ANSES

THYROGENOX

Screening of the activity of plant protection products on thyroid hormone signaling.

Amphibian models are combined with toxicogenomics approaches to study possible impacts on neurodevelopment.

Partners:
Laboratoire Watchfrog, ENS of Lyon

Financing:
ANSES

SVEH

The aim of SVEH was to create a mobile platform to monitor industrial waste water, in particular in the context of hospital and healthcare institutions. A laboratory van has been built integrating bioassays and innovative chemical analytical tools. It is available for measuring the environmental impact of chemical pollution in water.

Partners:
Laboratoire Watchfrog, TOXEM, PROFILOMIC, ALYXAN, Centre Hospitalier Sud Francilien d’Evry, PIREN SEINE, UNIV BORDEAUX 1 UMR CNRS EPOC, UNIV PARIS-SUD EQUIPE SPE UMR 8079, NOVA GREEN

Financing:
AP ECO INDUSTRIE (Ministry of Industry)

SOLUTIONS

A European consortium created to achieve the development of methods and strategies to help the authorities defining new water and environmental regulation to address chemical pollution. This consortium has published many guidance documents describing methodologies and suggesting how and when to apply these approaches.

Partners :
UFZ, Deltares, EI, IVL, JRC, KWR, Eawag, NIVA, LMC, OEKO, SU, RIVM, Alterra, CSIC, FB, Brunel, VITO, UNOL, Watchfrog, UNSPMF, MAXX, INERIS, UU, SYNCHEM, UOB, ULIV, ICPDR, DYNEX, NJU, RWTH, MU, Mermayde, IPB, HAM, UGOT, KOCMOC, UB, UQ, UNICAMP, Universidade Estadual de Campinas

Financing :
UE FP7

TOXSYN

Development of tools to study combination and low dose effects of endocrine active substances.

Focus on endocrine mechanisms related to the nuclear receptors PPAR and PXR known to be involved in physiological responses to drugs.

Partners:
Laboratoire Watchfrog, CNRS, ENS of Lyon, Inserm, University of Montpellier

Financing:
ANR

AMBRE

The aim of AMBRe was to develop amphibian models of neurodegenerative lesions to contribute towards screening of therapeutic drugs. The results of the project have led to the establishment of a service for the screening of drug candidates for neurodegenerative diseases.

Partners :
Laboratoire Watchfrog, CNRS, INSERM, Museum of Natural History, University of Orsay

Financing :
FUI (Ministry of Industry, IDF Region, Essonne Department)

THYPEST

Testing of the activity of two plant protection products on thyroid hormone signaling.

Amphibian models are combined with behavioral observations, histology, and gene expression approaches.

Partners:
Laboratoire Watchfrog, CNRS / Museum of Natural History