In vivo information...

integrated approach: taking into account the complete metabolism of the compound
amphibian model: main organs system like those of mammals and humans
in particular for the endocrine, angiogenic, immune and neurogenic systems
simultaneous poly-detection of multiple biological markers

... from in vitro tools:

simplicity of administering liquid sample by direct contact with the larvae
compatibility with standard equipment
small quantity of active substance needed: tests in micro-wells
high statistical validity: each set of eggs giving approx. 2000 individual tests
rapidity of screening: fluorescence detectable after a few hours
ease of reading results by measuring fluorescence via transparency
ease of quantification
minimization of ethical issues by virtue of using amphibian larvae
low cost of amphibian maintenance and production.

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